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Neuronal growth and synapse formation is regulated by a combination of activity-independent and activity-dependent mechanisms. In today's Science, E. Nedivi et al. describe CPG15, a molecule that enhances dendritic arbor growth...
A mutation in the gene for PAK-3, a molecule that is thought to play a variety of roles in the nervous system, has been implicated in a form of X-chromosome-linked mental retardation...
A research center focusing on advancing scientific understanding of brain disorders such as Alzheimer's disease, HIV dementia and stroke, was inaugurated earlier this month at UCSF...
The British science journal Nature announced that it is becoming a "full-fledged" electronic journal beginning with this week's issue (at <a href="http://www.nature.com">http://www.nature.com</a>)...
Estrogen has been shown in recent years to be a possible protective factor in Alzheimer disease, and now new studies suggest it may also protect against the risk of Parkinson's disease...
Secreted forms of amyloid precursor protein (APP) may play an important role in the formation and consolidation of memory, according to a study published in today's proceedings of the National Academy of Science...
A study published in last month's Neurology reports that professional soccer players are at significantly higher risk for long-term brain injuries that affect their mental function...
A diet rich in certain fruits and vegetables is known to protect against cancer and heart disease, and now a new animal study suggests nutrition can also stall the decline of brain function...
Can transgenic mice serve as a truly useful model for studying Alzheimer's disease? Studies of mice expressing an APP gene mutation that causes a form of familial AD have reported no neuronal loss...
The idea of treating developmental and neurodegenerative disorders by growing new brain cells has taken a major step forward, according to results of two studies...
It is known that aspirin and sodium salicylate suppress inflammation by inhibiting cyclooxygenase, an enzyme that triggers production of prostaglandin. It has been suspected that these compounds...
Current estimates predict that genome sequencing efforts may reveal between 3,000 and 10,000 new targets for drugs. In the December issue of Nature Biotechnology, Paul Negulescu and colleagues...
A new study elucidates the molecular mechanisms that may explain how mutations of the tau gene give rise to frontotemporal dementia and parkinsonism (FTDP-17), an inherited disorder that is similar to Alzheimer's...
Mutations in the β-amyloid precursor protein (APP), presenilin-1 and presenilin-2 cause inherited forms of Alzheimer's disease, but how do these protein interact, normally and in the disease process?...
Several years ago, Karen Hsiao and colleagues at the University of Minnesota reported that mice containing an FAD mutant form of the human amyloid precursor protein (APP) are impaired in their ability to learn...
